Lorenzo married twice.http://louis1j1sheehan1.blogspot.com
Lorenzo first married Clarice Orsini by proxy on February 7, 1469. She was a daughter of Giacomo Orsini, Lord of Monterotondo and Bracciano by his wife and cousin Maddalena Orsini. They had nine children:
* Lucrezia de' Medici (August 4, 1470 - November, 1553). She married Giacomo Salviati. Their daughter Francesca Salviati was mother to Pope Leo XI.
* Piero di Lorenzo de' Medici (February 15, 1471 - December 28, 1503).
* Twins born in March, 1472. Died shortly after birth.
* Maddalena de' Medici (July 25, 1473 - December, 1528). Married Franceschetto Cybo, an illegitimate son of Pope Innocent VIII.
* Pope Leo X (born Giovanni de' Medici; December 11, 1475 - December 1, 1521).
* Luisa de' Medici (1477 - 1488). She was betrothed to her cousin Giovanni de' Medici il Popolano.
* Contessina de' Medici (1478 - 1515). Married Piero Ridolfi.
* Giuliano di Lorenzo de' Medici, Duke of Nemours (March 12, 1479 - March 17, 1516). http://louis1j1sheehan1.blogspot.com
After Clarice's death, he married Philippina (Philippa) of Savoy, daughter of Philip II, Duke of Savoy. The couple had no children.[citation needed]
Two of his sons later became powerful popes. His second son, Giovanni, became Pope Leo X, and his adopted son Giulio (who was the illegitimate son of his slain brother Giuliano) became Pope Clement VII.
His first son and his political heir, Piero 'the Unfortunate', squandered his father's patrimony and brought down his father's dynasty in Florence. Another Medici, his brother Giovanni, restored it, but it was only made wholly secure again on the accession of a distant relative from a branch line of the family, Cosimo I de' Medici.
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